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Results of a recent study in MM patients, evaluated according to the International Staging System (ISS) (56, 57), revealed that ADO levels in BM plasma samples at diagnosis were higher in patients at an advanced stage (ISS = III) with symptomatic MM than in those at the earlier MGUS/SMM stages (pooled ISS = I-II) (58)

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Vegetarians and those over the age of 50 years old are at higher risk of being B12 deficient