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Also, pre-treatment with clinically relevant agents such as ATRA and Panobinostat could be used to enhance CD38 expression

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Dr Wasserfall cautions that this is a lifelong treatment: “Stopping the medication will result in the majority of the weight lost being regained.” Studies have backed this up, showing that patients tend to regain most of the weight after discontinuing semaglutide or other GLP-1 receptor agonists