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22 Hyperglycemia-driven ROS overproduction predominantly arises from two mechanisms: 66 Glucose Autoxidation (animal model, in vitro data): Direct generation of ROS via glucose metabolism intermediates by NOS, NADPH oxidases, xanthine oxidase, and hemeperoxidase enzymes, such as myeloperoxidase

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Shimizu Y, Dobashi K, Iizuka K, Horie T, Suzuki K, Tukagoshi H, et al