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However, prolonged exposure can overwhelm these defenses, tipping the balance toward ferroptosis, which could explain why chronic, low-level pollutant exposure is linked to long-term health risks
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When aging disrupts the balance of Nrf2 and NF-κB, it can increase ROS/RNS and activate inflammatory signaling pathways, thereby damaging cellular components and leading to cardiac injury (de Almeida et al., 2020)
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