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Overexpression of mitochondrial MnSOD also rescues the phenotype, as does the suppressor protein of ospus 1-1 , which encodes a mitochondrial pentapeptide repeat (PPR) protein
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Just like GLP1, OXM is a product of proglucagon gene believed to modulate energy homeostasis at least in part via GLP1R, although its GLP1R binding affinity is about 100 times lower than that of GLP1 (136)
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