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In several cell lines, ERK1/2 activation by morphine (presumably by a G βγ -dependent mechanism) was found to be blocked by PKC inhibition and did not involve nuclear translocation of activated ERK1/2

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Both reactions can be catalysed by protein disulphide isomerase (PDI) and possibly other oxidoreductases that share common domains with PDI (for a recent review, see Ellgaard & Ruddock, 2005)

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