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These effects were mediated by Nrf2 activation, increased HO-1 expression, and reduced oxidative stress, along with the modulation of MAPK proteins (JNK, ERK1/2, p-38), which are involved in inflammatory and neuroplasticity processes

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Aberrant elevation in ROS leads to neoplastic growth and progression of metastatic tumor, spearheaded by signaling events including PI3/Akt/mTOR, MAPK, PTEN, MMPs and VEGF/VEGFR etc