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The reduction in p27 Kip1 levels and the upregulation of cyclin D protein are thought to be the primary cell cycle effects of PI3K activation by RTKs [ 89 ]
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25 Other potential side effects of GHS peptides can include joint aches and headaches, but these side effects are much less common for GHS peptides than for HGH itself, because the body naturally regulates GHS peptides, dampening GH secretion when levels climb too high
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