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The model was initially developed in rats and later generalized to C57BL/6J mice (59) and is still mainly used in SD rats or C57BL/6J mice, and the intensity of mechanical nociceptive sensitization varies between strains, with C57BL/6J mice showing strong and persistent mechanical nociceptive sensitization, and C3H/HeSlc mice being less sensitive than other mice Strain (60)
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