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Beyond MAPK-mediated pathways, suppression of the α7 nicotinic acetylcholine receptor (α7-nAChR)–dependent cAMP/PKA and PI3K/AKT signaling pathways has also been implicated in NPP pathogenesis of NPP
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Current challenges in glutathione detection and biomarker analysis Quantification of GSH and related biomarkers like oxidized glutathione (GSSG) and the GSH/GSSG ratio is both clinically and research-wise challenging, predominantly due to preanalytical instability, methodological diversity, and biological interpretation difficulty
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