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It is a useful reminder that not every deviation from a native sequence is a potency argument, and that reading a modification correctly requires knowing what it was for

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In this species, inflammatory bowel disease (IBD), alimentary lymphoma, pancreatitis, cholangitis/cholangiohepatitis [29,30,35], and exocrine pancreatic insufficiency (EPI) [55] are the diseases frequently associated with cobalamin deficiency [29,30,35]