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[2] [1] For patients with neurological symptoms , hydroxocobalamin 1 mg is given intramuscularly on alternate days until no further improvement occurs, followed by maintenance injections every two months for life

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Research demonstrates that copper-binding peptides including GHK-Cu suppress the NF-κB pathway through direct molecular interactions, with nuclear translocation of NF-κB p65 decreased by approximately 30% upon treatment and molecular modeling showing specific peptide sequences exhibit high binding affinity to NF-κB p65 (up to -8.8 kcal/mol)