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Silverstein said he decided to investigate the over-prescribing of B12 shots, because "as an internal medicine resident, I have seen many patients come into the emergency department, and they were getting B12 injections without having a really good reason for it." His study could not determine why family physicians were prescribing it inappropriately — including whether it was initiated by the doctor or at the request of the patient

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PRP (platelet-rich plasma) provides a heterogeneous cocktail of autologous growth factors (PDGF, TGF-beta, IGF-1), but its composition varies from one draw to another