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doi:10.1016/j.jormas.2022.06.015

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As nucleostemin expression is generally downregulated in the stages of differentiation, downregulation of nucleostemin by curcumin indicated that curcumin could induce differentiation of tendon stem cells, even at lower concentrations of 1.6 and 3.2 µM, demonstrating that curcumin was effective to promote the differentiation of tendon stem cells