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Thus, in the early 1990s, pentadecapeptide BPC 157 [1,3,4,9,32,33,34,92] appeared as a late offshoot of the cytoprotection–organoprotection concept of Robert and Szabo [32,33,34,35,36,37,38,39,40,41,42], for epithelial and endothelial protection

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A fixed effect meta-analysis increased the significance of the observed association ( P = 1.1 × 10 −10 , odds ratio = 0.54)