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Toni Choueiri, KEYNOTE-564 12 is the first adjuvant IO therapy trial to improve overall survival (as well as previously shown improved DFS) in any malignancy (HR 0.62, 95% CI 0.44-0.87, p = 0.002): The decision for adjuvant therapy involves weighing the risks and benefits of the following: Disease-free survival Overall survival Risk of over treatment Side effects of therapy Quality of life Indeed, there have been decades of progress in first-line metastatic RCC therapy, from an overall survival benefit of 10 months in 1992 for cytokine therapy to 56 months in 2018 for combination immune checkpoint blockade and targeted therapy: Dr

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doi:10.1016/j.freeradbiomed.2011.04.013