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The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease

7.2 Future directions: gene editing and precision medicine for mtDNA The future of mitochondrial medicine lies in moving beyond symptom management to directly target the genetic root of dysfunction—the mtDNA itself

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confirmed that the lower antioxidant enzyme activities might lead to oxidative stress through the oxidation of DNA and protein carbonyl content (general indicator marker of protein oxidation), which may affect the health status of FM patients [32]