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Redness over an involved joint (gout is highly inflammatory) Involvement of the base of the big toe on one side (the most common site for gout) Involvement of the joints at the middle of the foot Uric acid elevation on blood testing X-ray findings of swelling of joints which is not symmetrical Joint fluid is tested for infection and is negative

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While it’s not totally understood yet how this happens, some researchers theorize it could have something to do with the medication’s impact on intrinsic factor