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However, when MCL-1 is bound by SAHB D , its anti-apoptotic activity is inhibited, thereby sensitizing the cancer cells to apoptosis triggered by death receptor stimulation [91] (see Figure 1)
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“Vyzulta [latanoprostene bunod, Bausch + Lomb] in November 2017, Rhopressa [netarsudil, Aerie Pharmaceuticals] in December 2017, and Rocklatan, the fixed-dose combination of netarsudil and latanoprost [Aerie Pharmaceuticals], in March 2019.” “Those new medications represent the first approved novel agents in more than 2 decades when prostaglandins and alpha agonists were approved in 1996,” said Albert Khouri, MD
