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Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference

Laboratory Research

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Methionine synthase catalyzes the transfer of a methyl group to S-adenosyl-homocysteine, generating S-adenosyl-methionine and hence methionine, while methylmalonyl-CoA mutase catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, which then enters the citric acid cycle (Figure 1) [4,5,6]