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3 However, the evidence for the effectiveness of B 12 injections over oral treatments is limited.11,15 Two Cochrane reviews of randomised controlled trials (RCTs) found that intramuscular and oral formulations (of at least 1000 μg a day) were equally effective and safe in restoring B 12 serum levels

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Overhage J, Campisano A, Bains M, Torfs EC, Rehm BH, Hancock RE