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Nature 424 , 778–783 (2003)
K oligopeptide
SIZE:30 Capsules
Hydroxamate HDAC Inhibitors Hydroxamate-structured HDAC inhibitors, vorinostat and belinostat (Scheme 20), belong to the classical tri-partite ligands of zinc-dependent histone deacetylases, comprising an aromatic cap group, a hydrophobic aliphatic linker, and a terminal hydroxamate moiety that acts as a bidentate Zn 2+ chelator within the catalytic center of the enzyme [197]
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