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In a murine model of UVB-induced photo-carcinogenesis, topical treatment of the mice with the NO donor NO-exisulind reduced the overall aggressiveness of the tumor, increased the expression of the epithelial marker E-cadherin, reduced levels of various EMT markers, including fibronectin and N-cadherin, and downregulated EMT inducers such as Snail, Slug, and Twist (Singh, Chaudhary et al

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CLSM analysis indicated that LPS was confined to the stratum corneum, while MMPTs were mainly localized in the deeper skin layers, indicating their potential to facilitate transdermal delivery of SIN