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In view of the need to at the same time preserve its many helpful functions, the challenge of modulating selectively the TNF pathway for neuroprotection is that to account for the overlapping biological functions of TNF-alpha/TNFR with that of other ligand/receptor superfamily members [200] and the presence of genetic polymorphisms in individuals with MS

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[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Walker K.A., Le Page L.M., Terrando N., Duggan M.R., Heneka M.T., Bettcher B.M