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Sulforaphane from cruciferous vegetables (e.g., broccoli), bardoxolone methyl, and dimethyl fumarate have demonstrated promise in preclinical models by restoring redox balance, reducing BP, and attenuating end-organ damage effects attributed to enhanced HO-1-mediated vasodilation, reduced NOX activity, and suppression of pro-inflammatory NF-κB signaling (Alves et al., 2025