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Although the peak levels of ERK activity, indicated by the density of the phospho-ERK bands, were not different between WT and Gsr −/− macrophages, ERK activity was slightly higher at the later time points (2 and 4 h) in Gsr −/− macrophages

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On the other hand, αKG stimulates dihydrolipoamide dehydrogenase (DLD) to generate mitochondrial ROS and to increase local iron level during cystine deprivation-induced ferroptosis