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Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice [PMID: 24051248] Laboratory literature summary: Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

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In β₃-AR knockout mice, chronic AOD‑9604 failed to reduce fat mass or increase plasma glycerol—confirming that the long-term lipolytic effects depend on functional β₃-AR signaling [3]