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With sub-nanomolar affinity for its interaction with CaM and limited abundance of CaM in ECs, eNOS expression level and activation in turn significantly influences the CaM-binding proteome in ECs (Tran et al., 2005

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Compared to cyanocobalamin, it is characterised by a stronger binding to tissue and serum proteins, which means a delayed excretion with the urine and thus a longer availability for absorption into the tissue stores