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For example, in comparison with trastuzumab, a monoclonal antibody (mAb) with a MW of 185 kDa, small molecule tyrosine kinase inhibitors such as lapatinib, afatinib, and erlotinib, are superior at crossing the BBB [15] , offering several advantages in the treatment of brain metastasis associated with human epidermal growth factor receptor 2-positive tumors [16]

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doi: 10.1007/s11356-016-6947-z