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Additional tirzepatide safety concerns include risk of acute gallbladder disease (presenting as right upper quadrant pain, fever, or jaundice), acute kidney injury from dehydration (especially if severe gastrointestinal symptoms occur), and hypersensitivity reactions

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In activated integrins (E + H + ), the hybrid domain (β-subunit) swings away from the α-chain, and the membrane proximal regions unclasp