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This GSH/GPX4 system works as the main ferroptosis surveillance system in healthy cells, and, therefore, the inhibitions of system Xc − by erastin and GPX4 by RSL3 result in ferroptosis (Dixon et al., Figure 2 In addition to the GSH/GPX4 system, another system to avoid the accumulation of peroxidized lipids has been discovered
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However, the effectiveness of NAC supplementation relies on the body’s capacity to produce glutathione from precursor molecules, a process limited by age and potentially genetic factors or health conditions such as liver dysfunction [23]
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