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DED is characterized by a complex multifactorial aetiology involving tear film instability, ocular surface inflammation and neurosensory abnormalities, leading to symptoms of ocular discomfort, visual disturbances and potential damage to the ocular surface (Craig et al., 2017)

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The chemical signature that we discovered is evidence that CFS is an objective metabolic disorder that affects mitochondrial energy metabolism, immune function, GI function, the microbiome, the autonomic nervous system, neuroendocrine, and other brain functions