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37 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Location of UGTs in the body807060 Number 81 (n=5) Number 74 (n=5)5040302010 0Concentration (pmol/mg LC-MS of UGT Proteotypic Peptides protein) UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2B4 UGT2B7 UGT2B10 UGT2B15 UGT2B17Hepatic UGTs 0 10 time (min) 20 30• Antibodies are not available for many UGTs due to high homology, nor are the ones available always very specific.• mRNA supports diverse UGT2B isoform disposition in tissues

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By following responsible supplementation practices and consulting qualified healthcare professionals, individuals can better support their long-term health while minimizing unnecessary risks.