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The combination of EP-B2 (ALV001) and SC-PEP (ALV002) in a 1:1 ratio (ALV003, also known as Latiglutenase [35]) showed promising results in phase 1b-2a clinical studies, demonstrating significant protection from the development of villous atrophy and intraepithelial lymphocytosis in CeD subjects in remission who were challenged with the enzymes plus gluten versus placebo plus gluten [67,68]

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By addressing the limitations, challenges, and clinical relevance of these preclinical models, it seeks to provide a roadmap for improving their translational potential

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