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On the one hand, the electron transport chain includes ATP synthase, coenzyme Q (CoQ10), cytochrome c (Cytc), and the respiratory complexes CI-IV, proteins that are in the inner membrane of the mitochondrion and that are originated by the unification of units encoded in both the mtDNA and the DNA of the mitochondrial nucleus [101]
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This metabolic reprogramming is driven by key transcriptional regulators, such as SREBPs, which are potential targets for cancer therapy [181]
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