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BPC-157 has been evaluated in multiple TBI preclinical models with results suggesting multi-mechanism neuroprotective activity: BBB protection: BPC-157 administration following experimental TBI (weight-drop or fluid percussion injury models in rodents) reduces BBB disruption as measured by Evans Blue dye extravasation, tight junction protein preservation (ZO-1, occludin, claudin-5), and brain water content (oedema assessment)

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