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CYP2D6 pharmacogenetics and opioids CYP2D6-metabolized opioids tramadol, codeine, and hydrocodone account for the majority of opioid prescriptions written in the U.S., accounting for more than 50 million opioid prescriptions dispensed in 2020 [32,33]
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A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
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