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Either genetic or pharmacologic inhibition of TrxR1 activity induces Nrf2 without inducing oxidative stress, indicating that a part of the stress-sensing regulatory mechanism of Nrf2 is controlled by TrxR1 [49, 173–176]

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doi: 10.1038/nature10350 8 LabuschagneCFVan Den BroekNJMackayGMVousdenKHMaddocksODK