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At baseline, AD fibroblasts showed a slight, though not significant, decrease of TOM20 compared to controls (Figure 3B)

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Despite low numbers of indels, SigProfiler extracted two de novo indel signatures which were reconstructed by a combination of known COSMIC signatures ID1, ID2 (both polymerase slippage during replication), ID9 (unknown cause) and ID23 (aristolochic acid exposure) (Fig