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Mechanistically, DJ-1 prevents the enhanced inhibitory interaction between SAHH and its negative regulator S-adenosylhomocysteine hydrolase-like 1 protein (AHCYL1), thereby promoting the formation of catalytically active SAHH tetramers
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Otras causas de colestasis sin fallo hepático, en el período neonatal y de lactante (ver capítulo correspondiente) son: el déficit de alfa-1-antitripsina, síndrome de Alagille, colestasis intrahepática familiar progresiva, fibrosis quística, enfermedad de Niemann-Pick A y C, enfermedad de Zellweger, panhipopituitarismo, quiste de colédoco, perforación espontánea de la vía biliar, sepsis, infección urinaria, tóxicos, nutrición parenteral y multifactorial