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A recent study on mosquitofish ( Gambusia affinis ) that were exposed to TCS showed that the up-regulations Sirt1 and Sirt2 in Sirtuin family could activate the Nrf2/ARE signaling pathway and the down-regulations of miR-34b and the up-regulations of miR-34a , miR-144, and miR153a-5p modulated the Nrf2/ARE signaling pathway [234]

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Holecek, Side Effects of Long‐Term Glutamine Supplementation, J Parenter Enteral Nutr 37 (2013) 607–616