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Myelin protein levels and oligodendrocyte number are normal in the CC of treatment-naïve SphK2 -/- mice at 5 months of age, however the loss of mature oligodendrocytes was more severe in SphK2 -/- compared to WT mice after six weeks of cuprizone feeding

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Using a fresh needle and syringe for each reconstitution, rather than reusing equipment, is one of the simplest ways to reduce particulate and microbial contamination risk