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Well it is often also caused by a mutation to the JAK2 gene 8 – this leads to the pathway being chronically activated, making too many MEPs, meaning too many RBCs, as demonstrated nicely by the image below 9 (click for full size image): The Risk of Elevated HCT and/or Haemoglobin With an increase in RBCs and subsequent HCT, we will ultimately see an increase in arterial blood pressure
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