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The functional complementarity between the two subfamilies is manifest in many contexts, for example, in primordial germ cell development, 64 hair follicle progenitor differentiation, 65 and epithelial-mesenchymal transitions (EMT)
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The developing vasoconstrictive effects, increased stiffness and vasculitis appear physiologically with increasing age, but AH accelerates this process [6,12]
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