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GDF-5 is a member of the bone morphogenetic protein (BMP)/TGF-β superfamily, the possible candidate pathways of which for its neuroprotective effect include Smad and p38 mitogen-activated protein kinase (MAPK) pathways (Bella et al., 2009)

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composed of collagen fibers disposed in plate-like formations, fibroblasts, and ground substance with many nerve fibers but no blood vessels