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LND in combination with the chemotherapeutic agents, CDDP , and paclitaxel, presented a good activity and tolerability (137)

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CYP3A4 inhibition by ketoconazole yielded an IC 50 of 0.83 µM in iHLOs, comparable to HepaRG cells (0.42 µM) but less potent than the IC 50 (0.056 µM) from PHHs, demonstrating their applicability for studying CYP-mediated drug-drug interactions (Fig