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We documented bioavailability and biologic effects of a stable salt of SAMe (1,4-butanedisulfonate salt, Nutramax Laboratories, Nutramax Laboratories, USA) in healthy cats, cats with asymptomatic cholangiohepatitis, and dogs with glucocorticoid-induced vacuolar hepatopathy

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patented combination of 200 mg lidocaine alkalinized with sequential instillation of 8.4% sodium bicarbonate instilled once daily for 5 consecutive days with one hour retention), more patients in the treatment group (30% and 24% respectively) experienced clinically significant improvement compared to patients in the placebo group (10% and 11.5%, respectively)