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How 5-Amino-1MQ Inhibits NNMT 5-Amino-1MQ works by binding to the active site of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that catalyses the methylation of nicotinamide (a form of vitamin B3) into N-methyl nicotinamide using S-adenosylmethionine (SAM) as the methyl donor

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Fifty of 69 subjects (73%) survived following treatment with hydroxocobalamin