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Smith’s laboratory has successfully identified experimentally validated hits against all 16 proposed protein targets over the past few years via ensemble docking
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In both BDL and lithocholic acid-treated Huh-7 cells, the fall in expression of GSH synthetic enzymes coincided with an increase in the expression of several Maf proteins (c-Maf, MafG and MafK) as well as increased c-Maf and MafG nuclear binding to ARE
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