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Since the HL 2− and the H 3 L forms have four protonation isomers (microspecies) each, and the H 2 L − form has six microspecies, the molecule has sixteen different protonation states (microspecies) altogether [77]

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consider calcifediol when faster repletion or persistent SHPT is relevant), avoid mega-bolus dosing, and reserve active VDRAs for clear SHPT indications with careful calcium–phosphate–PTH monitoring—not as disease-modifying therapy in unselected CKD